Chemotherapy of Hormone Refractory Disease
By prostate Doc at 23 September, 2008, 7:43 pm
Historically, hormone refractory prostate cancer has been viewed as a condition minimally responsive to cytotoxic agents. This view is largely based on data generated before the mid-1990s using single agents or combinations of drugs. Doxorubicin, cyclophosphamide, vinblastine, cisplatin, fluorouracil, mitoxantrone, and estramustine have all been shown to have objective response rates <15%.
Read More >>Antiandrogen Withdrawal : Prostate
By prostate Doc at 16 September, 2008, 3:55 pm
Withdrawal of antiandrogens at progression is associated with a decline in PSA and improvement in clinical symptoms in approximately 20% of patients. The median duration of response is three to five months and is seen four weeks from with- drawal of flutamide.
Read More >>Secondary Hormonal Therapies : Prostate
By prostate Doc at 16 September, 2008, 8:28 am
Despite the high initial response to hormonal therapy, virtually all patients with metastatic disease progress. The median time to progression is 16-18 months. When progression occurs, primary androgen deprivation should be maintained.
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