Etiology and Clinical Factors : Prostate cancer
By prostate Doc at 6 October, 2008, 1:58 pm
Etiology
Epidemiologic factors associated with the development of prostate cancer in- clude age, genetic background, race, hormone status, and suspected dietary factors. Prostate cancer appears to be age-related occurring in 30% of men over age 50, and 80% of men over age 80, with an increase in incidence in each decade. It is impor- tant to [...]
Chemotherapy of Hormone Refractory Disease
By prostate Doc at 23 September, 2008, 7:43 pm
Historically, hormone refractory prostate cancer has been viewed as a condition minimally responsive to cytotoxic agents. This view is largely based on data generated before the mid-1990s using single agents or combinations of drugs. Doxorubicin, cyclophosphamide, vinblastine, cisplatin, fluorouracil, mitoxantrone, and estramustine have all been shown to have objective response rates <15%.
Read More >>Secondary Hormonal Therapies : Prostate
By prostate Doc at 16 September, 2008, 8:28 am
Despite the high initial response to hormonal therapy, virtually all patients with metastatic disease progress. The median time to progression is 16-18 months. When progression occurs, primary androgen deprivation should be maintained.
Read More >>Diagnosis of Prostate Cancer
By prostate Doc at 15 September, 2008, 8:34 am
Diagnosis of prostate cancer is most often made by needle biopsy of the prostate, following suspicion of its presence by digital rectal examination and PSA testing. Digi- tal rectal examination may strongly suggest the diagnosis; however, tissue confirma- tion is needed and may proceed by transrectal or transperineal biopsy of the prostate under a local [...]
Read More >>Clinical Features : Prostate cancer
By prostate Doc at 8 September, 2008, 4:28 pm
At presentation, 60% of patients have localized disease and only 15% have dis- tant metastases at presentation since the PSA era. The majority of patients are either asymptomatic or have bladder outlet symptoms, such as urgency and frequency. Patients with metastatic disease most often complain of bone pain which can be in the low back, [...]
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