Combined Androgen Blockade : Prostate
By prostate Doc at 7 October, 2008, 6:58 pm
It was proposed in the 1980s that testicular androgen deprivation combined with an antiandrogen would be superior to testicular androgen deprivation alone. This is referred to as combined androgen blockade (CAB) or maximal androgen blockade (MAB).
Read More >>Timing of Initiation of Therapy : Prostate
By prostate Doc at 9 September, 2008, 3:09 pm
The optimal time to begin either monotherapy or CAB has not been settled. Earlier therapy results in more toxicity and increased costs. Loss of libido and muscle mass, impotence, anemia, hot flashes, hair loss, acceleration of osteoporosis, and fatigue are all potential toxicities of therapy.
Read More >>Androgen Deprivation
By prostate Doc at 21 August, 2008, 3:26 pm
There are five methods of androgen deprivation which may be employed in the setting of advanced disease: 1. orchiectomy which removes the primary source of androgen production; 2. LHRH (luteinizing hormone releasing hormone) analogue therapy which depletes pituitary luteinizing hormone (LH) and results in subsequent down-regulation of LHRH receptors; 3. estrogen therapy which reduces LH [...]
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