Treatment of Advanced Prostate Cancer
Combined Androgen Blockade : Prostate
By prostate Doc at 7 October, 2008, 6:58 pm
It was proposed in the 1980s that testicular androgen deprivation combined with an antiandrogen would be superior to testicular androgen deprivation alone. This is referred to as combined androgen blockade (CAB) or maximal androgen blockade (MAB).
Read More >>Chemotherapy of Hormone Refractory Disease
By prostate Doc at 23 September, 2008, 7:43 pm
Historically, hormone refractory prostate cancer has been viewed as a condition minimally responsive to cytotoxic agents. This view is largely based on data generated before the mid-1990s using single agents or combinations of drugs. Doxorubicin, cyclophosphamide, vinblastine, cisplatin, fluorouracil, mitoxantrone, and estramustine have all been shown to have objective response rates <15%.
Read More >>Antiandrogen Withdrawal : Prostate
By prostate Doc at 16 September, 2008, 3:55 pm
Withdrawal of antiandrogens at progression is associated with a decline in PSA and improvement in clinical symptoms in approximately 20% of patients. The median duration of response is three to five months and is seen four weeks from with- drawal of flutamide.
Read More >>Secondary Hormonal Therapies : Prostate
By prostate Doc at 16 September, 2008, 8:28 am
Despite the high initial response to hormonal therapy, virtually all patients with metastatic disease progress. The median time to progression is 16-18 months. When progression occurs, primary androgen deprivation should be maintained.
Read More >>Timing of Initiation of Therapy : Prostate
By prostate Doc at 9 September, 2008, 3:09 pm
The optimal time to begin either monotherapy or CAB has not been settled. Earlier therapy results in more toxicity and increased costs. Loss of libido and muscle mass, impotence, anemia, hot flashes, hair loss, acceleration of osteoporosis, and fatigue are all potential toxicities of therapy.
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